Efektivitas Gambir (Uncaria gambir Roxb.) sebagai Anti Hiperkolesterolemia dan Stabilisator Nilai Darah pada Mencit Putih (Mus musculus) Jantan

Authors

  • Desfita Frinanda Laboratorium Riset Fisiologi Hewan, Jurusan Biologi, FMIPA Universitas Andalas, Kampus UNAND Limau Manis Padang – 25163
  • - Efrizal Laboratorium Riset Fisiologi Hewan, Jurusan Biologi, FMIPA Universitas Andalas, Kampus UNAND Limau Manis Padang – 25163
  • Resti Rahayu Laboratorium Riset Fisiologi Hewan, Jurusan Biologi, FMIPA Universitas Andalas, Kampus UNAND Limau Manis Padang – 25163

DOI:

https://doi.org/10.25077/jbioua.3.3.%25p.2014

Abstract

Research about the affectivity of gambier (Uncaria gambir Roxb.) as anti-hypercholesterolemic and stabilizer of blood value on the male white mice (Mus musculus) have been done from August to December 2013 in the Research Laboratory of Animal Physiology, Biology Department, Mathematics and Natural Sciences Faculty, Andalas University, Padang and Sejawat Clinical Laboratory, Padang. This study aimed to determine whether gambier could inhibit the increase in total cholesterol and stabilize blood value of white mice that were given with the leftover frying oil and to determine the best dose of gambier in inhibiting the increase in total cholesterol and stabilize blood value of white mice that were given with the leftover frying oil. This study used an experimental method completely randomized design (CRD) with five treatments and five replications. Treatment with giving the leftover frying oil and gambier dose of 50; 100; 150 and 200 mg/kg and control with giving the leftover frying oil without giving gambier. The result showed that the gambier could inhibit the increase in total cholesterol and stabilize blood of white mice that were given with the leftover frying oil and the best dose is 50 mg/kg body weight.


Keywords : Uncaria gambir Roxb., anti hypercholesterolemic, Mus musculus

References

Adriani, L. 2012. Komposisi dan Imbangan Bakteri pada Pembuatan Yoghurt terhadap Nilai Hematologik Mencit. Unpad. Bandung.

Amalia, A. 2009. Uji Efek Imunomodulator Ekstrak Etanol Gambir (Uncaria gambir R.) terhadap Aktivitas dan Kapasitas Fagositosis Sel Makrofag Peritonium Mencit secara In Vivo. Skripsi Program Studi Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UIN. Jakarta.

Badan POM RI. 2010. Acuan Sediaan Herbal Vol.5. Badan Pengawas Obat dan Makanan Republik Indonesia. Jakarta.

Broberg, C. S., B. E. Bax and D. O. Okonko. 2006. Blood Viscosity and Its Relationship to Iron Deficiency, Symptoms, and Exercise Capacity in Adults with Cyanotic Congenital Heart Disease. Journal of The American College of Cardiology 48: 356–365.

Dhalimi, A. 2006. Permasalahan Gambir (Uncaria gambir R.) di Sumatera Barat dan Alternatif Pemecahannya. Perspektif 5 (4): 46-59.

Diaz, M. N., B. Frey, J. A. Vita and J. F. Keaney. 1997. Antioxidants and Atherosclerotic Heart Disease. The New England Journal of Medicine 337(6): 408.

Ekawati. 2007. Pengaruh Teh Hitam (Camellia sinensis (L.)O.K.) terhadap Ketebalan Dinding Arteri Koronaria Tikus Putih (Rattus norvegicus) yang Diberi Diet Tinggi Lemak. PKMI Fakultas Kedokteran Universitas Gadjah Mada. Yogyakarta.

Ermiati. 2004. Budidaya, Pengolahan Hasil dan Kelayakan Usaha Tani Gambir (Uncaria gambir Roxb.) di Kabupaten 50 Kota. Buletin TRO.

Fadilah, S. 1999. Hubungan antara Stenosis Arteri Koroner dan Ketebalan Intima Media Arteri Karotis pada Penderita Penyakit Jantung Koroner dengan Diabetes Melitus Tidak Tergantung Insulin. Jurnal Kardologi Indonesia 14: 1-6.

Fajrin, F. A. 2010. Aktivitas Ekstrak Etanol Ketan Hitam untuk Menurunkan Kadar Kolesterol. Jurnal Farmasi Indonesia 5 (2): 63-69.

Gandasoebrata, R. 1989. Penuntun Laboratorium Klinik. Dian Rakyat. Jakarta.

Guyton. A. C and J. E. Hall. 2006. Buku Ajar Fisiologi Kedokteran Edisi 11. Diterjemahkan oleh Irawati, D. Ramadhani, F. Indiyani, F. Dany. I. Nuryanto, S. S. P. Rianti, T. Resmisari dan Y. J. Suyono. EGC. Jakarta.

Heitzman, M. E., C. C. Neto, E. Winiarz, A. J. Vaisberg dan G. B. Hammond. 2005. Ethnobotany, Phytochemistry and Pharmacology of Uncaria (Rubiaceae). Phytochemistry 66: 5-29.

Horigome, H., Y. Hiramatsu, O. Shigeta and T. Nagasawa. 2002. Overproduction of Platelet Microparticles in Cyanotic Congenital Heart Disease With Polycythemia. Journal of The American College of Cardiology 39: 1072–1077.

Kaplan, A and L. L. Szabo. 1979. Clinical Chemistry: Interpretation and Techniques. Lea and Febiger. Philadelphia.

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How to Cite

Frinanda, D., Efrizal, .-., & Rahayu, R. (2015). Efektivitas Gambir (Uncaria gambir Roxb.) sebagai Anti Hiperkolesterolemia dan Stabilisator Nilai Darah pada Mencit Putih (Mus musculus) Jantan. Jurnal Biologi UNAND, 3(3). https://doi.org/10.25077/jbioua.3.3.%p.2014

Issue

Vol. 3 No. 3 (2014)

Section

Articles

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